| Pair Name | Curcumin, Irinotecan | ||
| Phytochemical Name | Curcumin (PubChem CID: 969516 ) | ||
| Anticancer drug Name | Irinotecan (PubChem CID: 60838 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Curcumin, Irinotecan | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | CD24 | hsa100133941 |
| Down-regulation | Expression | CD44 | hsa960 | |
| Down-regulation | Expression | EPCAM | hsa4072 | |
| Down-regulation | Expression | PROM1 | hsa8842 | |
| In Vitro Model | LoVo | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0399 |
| Result | The present data demonstrated that curcumin attenuated resistance to chemotherapeutic drugs through induction of apoptosis of CSCs among colon cancer cells. These findings may provide novel evidence for the therapeutic application of curcumin in CRC intervention. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells. Int J Oncol. 2018 Sep;53(3):1343-1353. doi: 10.3892/ijo.2018.4461. | Click |
